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If you’re looking for the best bet to make among the 14 NFL matchups in Week 10, we’re on the Buccaneers at +5.5 in terms of the point spreads. Don’t stop there, though — scroll down, because we have lots more suggestions, which you could take advantage of in a parlay.

Take advantage of our predictions to make your NFL picks this week. has all the information you need to begin betting on the NFL.

Best Week 10 Spread Bets

Jump to Matchup:

NYJ-ARI | MIA-LAR | PIT-WAS | ATL-NO | DET-HOU

Pick: Cardinals -1 vs. Jets

• Matchup: New York Jets at Arizona Cardinals
• Projected Winner & Margin: Cardinals by 11.7 points ()
• Spread: Cardinals -1
• Time: 4:25 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Pick: Rams -2.5 vs. Dolphins

• Matchup: Miami Dolphins at Los Angeles Rams
• Projected Winner & Margin: Rams by 16.7 points ()
• Spread: Rams -2.5
• Time: 8:15 p.m. ET
• Date: Nov. 11
• TV Channel: ESPN
• Live Stream: (Regional restrictions may apply)

Pick: Commanders -3 vs. Steelers

• Matchup: Pittsburgh Steelers at Washington Commanders
• Projected Winner & Margin: Commanders by 4.7 points ()
• Spread: Commanders -3
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Pick: Falcons -3.5 vs. Saints

• Matchup: Atlanta Falcons at New Orleans Saints
• Projected Winner & Margin: Falcons by 5.3 points ()
• Spread: Falcons -3.5
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: FOX
• Live Stream: (Regional restrictions may apply)

Pick: Lions -3.5 vs. Texans

• Matchup: Detroit Lions at Houston Texans
• Projected Winner & Margin: Lions by 8.3 points ()
• Spread: Lions -3.5
• Time: 8:20 p.m. ET
• Date: Nov. 10
• TV Channel: NBC
• Live Stream: (Regional restrictions may apply)

. Use those stats when making your NFL picks and

Best Week 10 Total Bets

Jump to Matchup:

Under 49 – Lions vs. Texans

• Matchup: Detroit Lions at Houston Texans
• Projected Total: 47.7 points ()
• Time: 8:20 p.m. ET
• Date: Nov. 10
• TV Channel: NBC
• Live Stream: (Regional restrictions may apply)

Under 45.5 – Steelers vs. Commanders

• Matchup: Pittsburgh Steelers at Washington Commanders
• Projected Total: 44.2 points ()
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Under 41.5 – Broncos vs. Chiefs

• Matchup: Denver Broncos at Kansas City Chiefs
• Projected Total: 41.0 points ()
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Over 50.5 – 49ers vs. Buccaneers

• Matchup: San Francisco 49ers at Tampa Bay Buccaneers
• Projected Total: 52.4 points ()
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: FOX
• Live Stream: (Regional restrictions may apply)

Under 46 – Bills vs. Colts

• Matchup: Buffalo Bills at Indianapolis Colts
• Projected Total: 45.2 points ()
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

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