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After studying the 13 games on the Week 14 schedule in the NFL, our best against-the-spread choice is Cardinals -2.5. For more tips, which could lead to parlay opportunities, continue reading.

NFL Picks Against the Spread – Week 14

Jump to Matchup:

Pick: Cardinals -2.5 vs. Seahawks

• Matchup: Seattle Seahawks at Arizona Cardinals
• Projected Winner & Margin: Cardinals by 6.2 points ()
• Spread: Cardinals -2.5
• Time: 4:05 p.m. ET
• Date: Dec. 8
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Pick: Lions -3.5 vs. Packers

• Matchup: Green Bay Packers at Detroit Lions
• Projected Winner & Margin: Lions by 9.1 points ()
• Spread: Lions -3.5
• Time: 8:15 p.m. ET
• Date: Dec. 5
• TV Channel: Amazon Prime Video
• Live Stream: (Regional restrictions may apply)

Pick: Jaguars +3.5 vs. Titans

• Matchup: Jacksonville Jaguars at Tennessee Titans
• Projected Winner & Margin: Titans by 3.1 points ()
• Spread: Titans -3.5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Pick: Bears +4 vs. 49ers

• Matchup: Chicago Bears at San Francisco 49ers
• Projected Winner & Margin: 49ers by 3.9 points ()
• Spread: 49ers -4
• Time: 4:25 p.m. ET
• Date: Dec. 8
• TV Channel: FOX
• Live Stream: (Regional restrictions may apply)

Pick: Chiefs -4 vs. Chargers

• Matchup: Los Angeles Chargers at Kansas City Chiefs
• Projected Winner & Margin: Chiefs by 4.5 points ()
• Spread: Chiefs -4
• Time: 8:20 p.m. ET
• Date: Dec. 8
• TV Channel: NBC
• Live Stream: (Regional restrictions may apply)

Pick: Bills -4.5 vs. Rams

• Matchup: Buffalo Bills at Los Angeles Rams
• Projected Winner & Margin: Bills by 9.0 points ()
• Spread: Bills -4.5
• Time: 4:25 p.m. ET
• Date: Dec. 8
• TV Channel: FOX
• Live Stream: (Regional restrictions may apply)

Pick: Giants +5 vs. Saints

• Matchup: New Orleans Saints at New York Giants
• Projected Winner & Margin: Saints by 2.4 points ()
• Spread: Saints -5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: FOX
• Live Stream: (Regional restrictions may apply)

Pick: Vikings -5.5 vs. Falcons

• Matchup: Atlanta Falcons at Minnesota Vikings
• Projected Winner & Margin: Vikings by 14.7 points ()
• Spread: Vikings -5.5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: FOX
• Live Stream: (Regional restrictions may apply)

Pick: Cowboys +5.5 vs. Bengals

• Matchup: Cincinnati Bengals at Dallas Cowboys
• Projected Winner & Margin: Bengals by 0.5 points ()
• Spread: Bengals -5.5
• Time: 8:15 p.m. ET
• Date: Dec. 9
• TV Channel: ESPN
• Live Stream: (Regional restrictions may apply)

Pick: Steelers -6.5 vs. Browns

• Matchup: Cleveland Browns at Pittsburgh Steelers
• Projected Winner & Margin: Steelers by 17.2 points ()
• Spread: Steelers -6.5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Pick: Jets +6.5 vs. Dolphins

• Matchup: New York Jets at Miami Dolphins
• Projected Winner & Margin: Dolphins by 5.6 points ()
• Spread: Dolphins -6.5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Pick: Buccaneers -6.5 vs. Raiders

• Matchup: Las Vegas Raiders at Tampa Bay Buccaneers
• Projected Winner & Margin: Buccaneers by 19.0 points ()
• Spread: Buccaneers -6.5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Pick: Eagles -12.5 vs. Panthers

• Matchup: Carolina Panthers at Philadelphia Eagles
• Projected Winner & Margin: Eagles by 27.9 points ()
• Spread: Eagles -12.5
• Time: 1 p.m. ET
• Date: Dec. 8
• TV Channel: FOX
• Live Stream: (Regional restrictions may apply)

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